Mutual exclusion of ASXL1 and NPM1 mutations in a series of acute myeloid leukemias
نویسندگان
چکیده
منابع مشابه
Role of ASXL1 and TP53 mutations in the molecular classification and prognosis of acute myeloid leukemias with myelodysplasia-related changes
Acute myeloid leukemias (AML) with myelodysplasia-related changes (AML-MRC) are defined by the presence of multilineage dysplasia (MLD), and/or myelodysplastic syndrome (MDS)-related cytogenetics, and/or previous MDS. The goal of this study was to identify distinct biological and prognostic subgroups based on mutations of ASXL1, RUNX1, DNMT3A, NPM1, FLT3 and TP53 in 125 AML-MRC patients accordi...
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BACKGROUND Mutations in the nucleophosmin (NPM1) gene have been solely associated with childhood acute myeloid leukemia (AML). We evaluated the frequency of NPM1 mutations in childhood AML, their relation to clinical and cytogenetic features and the presence of common FLT3 and RAS mutations. RESULTS NPM1 mutations were found in 8% of cases. They involved the typical type 'A' mutation and one ...
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چکیده ندارد.
15 صفحه اولDetection of R882 Mutations in DNMT3A Gene in Acute Myeloid Leukemia: A Method Comparison Study
Background: Somatic mutations in the hotspot region of the DNA-methyltransferase 3A (DNMT3A) gene were recurrently identified in acute myeloid leukemia (AML). It is believed that DNMT3A mutations confer an adverse prognosis for AML patients. These lines of evidence support the need for a rapid and cost-efficient method for the detection of these mutations. The present study aimed to establish h...
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ژورنال
عنوان ژورنال: Leukemia
سال: 2009
ISSN: 0887-6924,1476-5551
DOI: 10.1038/leu.2009.218